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The eMatchPhysicians Blog 
Skin Cancer Pill Reduces Tumors by 30%
Posted on: Monday, June 8, 2009
In a preliminary trial, a drug developed by Roche and Plexxikon Inc. has shrunk advanced melanoma tumors by 30%, even in cases where it has spread to other areas. The drug works through blocking cellular mutation in BRAF, a cellular pathway that occurs in 60% of melanomas and 8% of all solid tumors.
Results from the Phase 1 trial were released at the meeting of the American Society of Clinical Oncology in Orlando. The drug is currently known as PLX4032 and the trials were conducted through the University of Pennsylvania. Dr Keith Flaherty, the trial’s lead investigator, stated that ‘PLX4032 has shown both tumour shrinkage and delay in tumour progression in patients whose tumours harbour a BRAF mutation, as well as improved quality of life for symptomatic patients’.
Melanoma is one of the deadliest forms of skin cancer and treatment options have been limited to traditional methods of cancer care until now. This is huge news for those who may develop advanced melanoma in the future; some participants went as long as six months without symptoms because of the drug.
Tags: health care, healthcare, skin cancer
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